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For example, preclinical mouse models of AD showed that intra-cerebral injection of anti-A-antibody (AAA) resulted in reduction of A plaques (Solomon et al., 1997), whereas its systemic administration failed, because of the difficulty to penetrate the BBB (Wilcock et al., 2004)

75 WadaK.SugimoriH.BhideP

Biological Chemistry, 2014

These side effects are generally mild but can be discomforting

DSIP has since become a research tool for laboratory investigation of sleep architecture, hypothalamicpituitaryadrenal (HPA) axis modulation, and neuroendocrine stress response